Treatment for COVID-19

Treatment for COVID-19

See a video describing treatment options in العربية (Arabic) | မြန်မာစာ (Burmese) | Dari / دری | Français (French)| Kirundi | Maay Maay | नेपाली (Nepali) | Pashto /پښتو | Soomaali | Español (Spanish) | Swahili | Tiếng Việt (Vietnamese) | American Sign Language

Treatment options are available for people with COVID-19 who are considered high risk, with mild to moderate symptoms. Your health care provider will recommend the best treatment option for you, based on your symptoms and your health history. Please note that due to a federal supply shortage, availability of all COVID-19 therapeutics are limited throughout Vermont.

What are COVID-19 therapeutic treatments?


Your body naturally makes antibodies to fight infection. However, your body may not have sufficient antibodies to recognize a new virus like the one that causes COVID-19. Monoclonal antibodies like Sotrovimab are made in a laboratory and are given to patients directly with an infusion into a vein (intravenously, or through an IV).   

The antibodies attach to the virus that causes COVID-19, which then blocks the virus from entering cells of the body. So treatment with monoclonal antibodies may slow the infection.  They provide temporary, enhanced immunity, which can help keep a person with COVID-19 from progressing to more severe symptoms.


Antiviral treatments like PaxlovidTM or Molnupiravir include a drug that blocks the activity of a specific enzyme needed for the virus that causes COVID-19 to replicate. This medication is taken by mouth. Like monoclonal antibodies, they can help keep a person with COVID-19 from progressing to more severe symptoms.

Who should get covid-19 treatments?

If you are age 65 or older or have a high-risk medical condition and have mild to moderate symptoms, reach out to your health care provider to ask about monoclonal antibody treatment — as soon you get your positive test result. The treatment works best in the first five days and can reduce the chance of being hospitalized by 70%.

Find out if you are high risk

How to get monoclonal antibody treatment

Your health care provider can refer you to an infusion center where monoclonal antibodies can be given. There are different types of treatments available. Your health care provider will help determine which one is right for you.

If you do not have a healthcare provider, call the Combat COVID Monoclonal Antibodies Call Center at 1-877-332-6585 to find out who to talk with about your symptoms and treatment.

There is no cost to anyone for the antibodies themselves, but there may be treatment fees. If you do not have insurance, ask the facility if there will be a charge.

How does the treatment work?

Depending on the treatment you receive, the whole process takes about 2 to 3 hours.

First, the medical staff conduct a screening; then they start an IV, which delivers the monoclonal antibodies to your body in just over an hour. It takes less time if the treatment is offered to you as a series of shots under the skin. Afterward, the medical team will have you stay at the infusion center for another hour to be sure you do not have an allergic reaction or any other side effects. These reactions are rare, but the medical team must observe you for this hour and can respond quickly if you have a reaction.

Even if you start feeling better, it is important to know that you could still spread the virus for a while. So, you will need to complete your isolation period.


For people who are immunocompromised or who are unable to receive the vaccine, there is a long-acting monoclonal treatment available that has received Emergency Use Authorization called Evusheld. This drug is administered through an injection and has shown a 77% reduction in developing COVID-19 symptoms. Talk to your provider to see if this product is an option for you.